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Colossal Biosciences

At Colossal Biosciences, we endeavor to jumpstart nature’s ancestral heartbeat

About Colossal Biosciences

Colossal will revolutionize history and be the first company to use CRISPR technology successfully in the de-extinction of previously lost species. On the journey we will build radical new software tools and technologies to advance the science of genomics overall.

At Colossal Biosciences, we endeavor to jumpstart nature’s ancestral heartbeat. To see the woolly mammoth thunder upon the tundra once again. To advance the economics of biology and nutrition. To make humanity more human. And to reawaken the lost wilds of Earth. So we, and our planet can breathe easier.

These things, which were not achievable before, are now. In our laboratories. Through our breakthroughs in CRISPR and genetic engineering. We are leading the new charge of bioscience. We accept the responsibility. And we can see the light at the end of it all.

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Problem statement

Of all the root causes of modern extinction, the most hyperactive factors are human civilization and industry which are accelerating extinction at a pace unimaginable across the entire 4.5 billion year history of Planet Earth.

Traction information

-Sequenced and publicized two of the highest quality reference genomes to date for the African and Asian elephant
-Refined and verified Colossal’s list of identified mammoth-specific genes as targets for editing through its computations biology spin-out, Form Bio
-Built a leading embryology lab for endangered species work and started the process of refining protocols for elephant somatic cell nuclear transfer process
-Parallelized multiplex editing workflows to generate over 20 edits in high impact genes associated with core cold adaptation mammoth phenotypes

Milestones

Announced Efforts to Eradicate EEHV in Elephants

Announced efforts to eradicate EEHV in elephants in partnership with Paul Ling Ph.D. and Baylor College of Medicine. Also, Colossal launched its partnership with the University of Alaska Fairbanks for the Mammoth in the Classroom initiative, the first-of-its-kind children’s education and research project focused on mammoths in Alaska.

Artificial Derivation of Pluripotent Stem Cells

Became the first to artificially derive pluripotent stem cells in both Asian and African elephants, which are essential for in-vitro embryogenesis and gametogenesis

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