Biosensing will provide the foundation for next generation rapid diagnostic systems. We use biology as a circuit to create a portable, next generation diagnostic platform that uses highly sensitive and selective biosensors to cost effectively detect infectious disease related proteins at very low concentrations in saliva in 5 minutes. Our devices are cloud connected for data sharing, aggregation, and continuous disease surveillance reporting to decision makers. Our biggest advantage is that each test provides a quantitative report of copies of live virus present in saliva. This allows for high fidelity contact tracing and instant on-site assessment of risk to the public at points of entry, therefore slowing the spread of the next pandemic.