Updates, milestones, and links shared by AlphaRose Therapeutics.
A quick update:
It's been nonstop at AlphaRose! We just came back from JPM with some significant investor conversations, and heading to Saudi Arabia at the end of Jan for more. Our valuation is rising, and our team is growing! We have a $3M CLN open that should close soon, with $2.1M already filled. We're open to investors that want to make an impact in patients lives with genetic medicine, changing the way that we think about how we make and deploy the medicine of the future for patients.
Lastly, we're very excited about the MHRA and FDA guidances, that are doing what we've been preparing all along - approving the process of making medicines at scale. Check out this latest article from the economist, hot of the press: https://www.economist.com/science-and-technology/2026/01/19/treatment-of-a-teenager-with-an-ultra-rare-condition-is-a-medical-milestone
If you're interested in the future of medicine. Now is the time. The Note is almost filled, the minimum investment currently is $50k, and comes with warrants. After this note closes in Feb 2026, we enter our Series Seed Round with a significantly higher valuation, and terms. Reach out about the opportunity if it seems like a potential fit.
Patients are waiting,
Casey McPherson & AlphaRose Team
We are oversubscribed on the CLN, and raised it to $3M with <1M currently available. (Closes Feb 2026)
AlphaRose has built significant value over this last quarter, with 5B+ in potential revenue waiting to be unlocked. Our team is very excited about the incredible opportunities in front of us.
To that end, we are announcing a $2m Convertible Note that just opened, Oct 1st - Nov 30th for select investors. The note is filling fast. Please reach out to me immediately if you have interest. ([email protected] / 512.940.4164)
Some significant markers:
AlphaRose is poised to be a revenue generating company in 2026 and beyond, and we are excited about the impact we will be making for patients with genetic diseases for generations to come!
For more info on the note and a company update Click here: https://alpharose.info/introdeckcln2
Sincerely,
Casey McPherson and the AlphaRose Team
AlphaRose opened their second convertible note with favorable terms, with internal investors priority, from Oct 1st - Nov 30th 2025.
Designed and intiated studies on two new genetic treatments with our proprietary technology, ”SOT Caller” These treatments are estimated to each reach 300-700m in AR once approved.
Check out the latest article in NewsWeek featuring our founder's story. We have the technology to treat and even cure many of these diseases. The industry lacks the business models and systems to do it at scale and speed. AlphaRose aims to fix this problem. Patients are waiting!
https://www.newsweek.com/research-moves-slowly-rare-diseases-dontso-patients-arent-waiting-2090277

If you are considering a potential investment in children's health or biotechnology, we would love for you join. Intro to AlphaRose is a live session to provide you with a deeper understanding of A...
Our animal tox study we just completed showed no adverse events. This study is a smaller version of the IND enabling study we will be performing next. This gives AlphaRose confidence that Rosiphersen will be safe in human trials.
We filed a provisional patent for our new epigenetic platform, ”Sot Caller.” This technology has the potential of changing gene expression throughout the human body. In addition to new therapies we create with it, similliar technologies have produced licensing deals in the xB's. Our plan is to develop this modality with new treatments, and once reach sufficient data, we will be poised to execute partnerships with biotech and pharma.
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Musician Casey McPherson gave up his career to find a cure for his 9-year-old daughter Rose, who has an ultra-rare genetic disorder. Now, he says that his company is hopefully six months away from being able to give Rose her first treatment.
AUSTIN, Texas, April 29, 2025 /PRNewswire/ -- AlphaRose Therapeutics, an advanced preclinical-stage biotechnology company focused on developing and commercializing therapeutics for neurogenetic developmental diseases, today announces the acquisition of Alpha Anomeric SA, a French company with a novel proprietary oligonucleotide chemistry platform (abcDNA). AlphaRose is currently advancing its lead antisense oligonucleotide product, Rosiphersen, through IND-enabling studies with a goal of initiating clinical studies in early 2026. AlphaRose is also developing a novel gene control technology platform and the Alpha Anomeric chemistry platform has the potential to become an integral part of the AlphaRose platform and development programs. Terms of the transaction were not disclosed.
Alpha Anomeric is a French company founded to develop a novel oligonucleotide chemistry platform (”abcDNA”) invented at the University of Bern (CH) by Professor Christian Leumann and Doctor Damien Evoquez. Alpha Anomeric was founded by Doctor Wolfgang Renner together with lead investor Advent Life Sciences and has validated the potential for the technology to be applied broadly in oligonucleotide therapeutic constructs. The novel chemistry platform is designed to enhance the safety, efficacy and applicability of oligonucleotide therapeutics in a variety of disease settings.
Read more in the press release here: https://www.prnewswire.com/news-releases/alpharose-therapeutics-announces-acquisition-of-alpha-anomeric-sa-a-french-company-with-industry-leading-oligonucleotide-technology-302440678.html#:~:text=AlphaRose%20will%20maintain%20Alpha%20Anomeric,global%20basis%2C%20including%20throughout%20Europe.
All contracts, quotes, and plans assembled for manufacturing, fill and finish, regulatory and clinical partners for lead product, ”Rosiphersen.”
We completed due diligence and began launch of our Reg CF Round for 5m. www.startengine.com/alpharose
We completed our genetic graph database and initial algorithms to identify amenable genetic mutations.
We succesfuly in licensed our lead product, ”Rosiphersen” into AlphaRose Therpauetics from our partner ”The To Cure A Rose Foundation.”
Our Company launch with initial pre-seed capital from the Termeer Family Office.